Brilliant Board Review & CME

πŸŽ™οΈ Episode 23: Hot Flash Fix: Fezolinetant Makes Menopause Manageable

β€’ Season 1 β€’ Episode 23

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🧠 Problem:

80% of menopausal women suffer from vasomotor symptoms (hot flashes, night sweats).

Many can't take hormone therapy (VTE, CAD, breast CA).

πŸ’Š Fezolinetant:

NK3 receptor antagonist β€” first in class.

Reduces frequency and intensity of hot flashes.

Safe in patients who can’t take estrogen.

⚠️ Side Effects:

GI symptoms, transaminitis.

Requires liver function monitoring.

🧩 Clinical Takeaway:

A breakthrough for non-hormonal menopause management.

Ideal for patients at high risk or contraindications to HRT.